PGD / PGS Testing
Pre-implantation Genetic Diagnosis (PGD) and Pre-implantation Genetic Screening (PGS) test embryos for genetic conditions before transfer.
About PGD / PGS Testing
Pre-implantation Genetic Testing is an advanced technology that allows us to examine embryos for genetic abnormalities before they are transferred to the uterus during an IVF cycle. At Dr. Nagalakshmi Speciality Hospital, we offer PGD (Pre-implantation Genetic Diagnosis) for detecting specific inherited genetic disorders, and PGS (Pre-implantation Genetic Screening), now known as PGT-A, for screening chromosomal abnormalities. These tests help select the healthiest embryos for transfer, improving IVF success rates and reducing the risk of genetic disorders and miscarriage. This technology is particularly valuable for couples with known genetic conditions, advanced maternal age, or recurrent pregnancy loss.
Benefits
- Identifies embryos with genetic abnormalities before transfer
- Reduces risk of genetic disorders in offspring
- Improves IVF implantation and success rates
- Decreases miscarriage risk from chromosomal issues
- Enables informed family planning decisions
- Particularly beneficial for carriers of genetic conditions
Treatment Process
- 1 Genetic counseling and evaluation of family history
- 2 Standard IVF/ICSI cycle with egg retrieval and fertilization
- 3 Embryo biopsy on day 5 (blastocyst stage)
- 4 Genetic analysis of biopsied cells at specialized lab
- 5 Results review and selection of healthy embryos
- 6 Transfer of genetically normal embryo to the uterus
Frequently Asked Questions
What is the difference between PGD and PGS?
PGD tests for specific known genetic conditions (like thalassemia or sickle cell disease) when there is a family history. PGS (PGT-A) screens for overall chromosomal normality and is used more broadly, especially for women over 35 or those with recurrent IVF failures.
Does embryo biopsy harm the embryo?
Modern embryo biopsy techniques at the blastocyst stage are very safe. Only a few cells from the outer layer (which becomes the placenta) are removed, leaving the inner cell mass (which becomes the baby) completely untouched.
Who should consider PGD/PGS?
PGD/PGS is recommended for couples with known genetic disorders, women over 35-37, those with recurrent miscarriages, previous failed IVF cycles, or anyone wanting to maximize their chances of a healthy pregnancy.